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The PanCaT project develops a novel model for pancreatic ductal adenocarcinoma that allows precise genetic manipulation of tumors and their microenvironment. This model aims to enhance understanding of cancer biology and improve treatment strategies for this aggressive cancer.
Maintenance and drug resistance of pancreatic ductal adenocarcioma (PDAC) depends on cancer cell intrinsic mechanisms and a stroma that supports tumor growth.
Mouse models of human PDAC have provided important insights into the evolution of this highly lethal tumor, but there are no models that allow secondary genetic manipulation of autochthonous tumors, the tumor microenvironment or the metastatic host niche once the tumor has formed.We generated an inducible dual-recombinase system by combini…
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
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