CORDIS Project
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This project investigates the interactions between immune cells and epithelial stem cells in the pancreas, particularly during inflammation and regeneration. It aims to understand how these interactions may influence tissue recovery and tumor development.
Regulation of the epithelial stem cell compartment is critical for tissue homeostasis and regeneration.
Consequently, imbalance in this process, through acquisition of somatic mutations for instance, may give rise to tumorigenesis.
Emerging reports reveal that regulatory T cells (Tregs) can modulate epithelial stem cell dynamics in the skin, while type 2 innate lymphoid cells (ILC2s) are known to influence tissue-regeneration.
Recent work in our laboratory has elucidated that ILC2s crosstalk is…
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