CORDIS Project
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This project develops new imaging agents for fluorine-19 magnetic resonance imaging (MRI) by combining paramagnetic metal ions with small ligands. The goal is to enhance the performance of MRI scans, particularly for biological applications, by improving water solubility and reducing relaxation times.
19F MRI relies mainly on the use of fluorine-dense perfluorocarbon nanoemulsions.
However, poor water solubility, limited stability, droplet heterogeneity, rigorous liver accumulation of the particles, as well as the relatively long fluorine relaxation times often limit their applicability.
Fe(III) and Mn(II) have the most advantageous paramagnetic properties to shorten T1 relaxation time of 19F without strong line-broadening T2 effect, deleterious for 19F MRI detection.
The combination of these…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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