CORDIS Project
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This project focuses on developing new biomaterials loaded with conditioned media from mesenchymal stromal cells to enhance bone regeneration. By utilizing the paracrine factors released by these cells, the project aims to create an 'off-the-shelf' solution for treating bone defects without the need for cell implantati…
Regeneration of bone defects remains a critical challenge in orthopaedics.
Mesenchymal stromal cells (MSC) with biomaterials show huge promise for bone regeneration.
However, MSC die shortly after implantation and act as mediators, by secretion of paracrine factors (PF), rather than effectors of bone formation.
Importantly, it seems that delivery of cells themselves may not be required for therapeutic benefit.
When MSC are cultured in vitro they release PF into their conditioned media (MSC-CM) i…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
United States, Cambridge
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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