CORDIS Project
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This project investigates the relationship between the endoplasmic reticulum and mitochondria in neurons, particularly in the context of hereditary spastic paraplegia. Using Drosophila models, it aims to understand how alterations in endoplasmic reticulum organization affect mitochondrial function and calcium handling…
Axonal endoplasmic reticulum (ER) forms a continuous network of tubules that appears to occur ubiquitously in neurons, and has been compared to “a neuron within a neuron”.
Its importance is suggested both by its apparent ubiquity, and by the identification of several causative genes for the axon degenerative disease, hereditary spastic paraplegia (HSP), that encode proteins that contribute to ER modeling.
However, its physiological roles, and how it could influence axon degeneration, are poorly…
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