CORDIS Project
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This project investigates the role of proteins in shaping the endoplasmic reticulum within axons, particularly in the context of hereditary spastic paraplegia. The research will utilize Drosophila models to explore how mutations in these proteins affect axonal structure and function.
Axonal endoplasmic reticulum (ER) is a poorly characterised compartment that is mainly tubular, smooth, and forms a network for long distances along axons.
Many mutations for the motor axon degeneration disease, hereditary spastic paraplegia (HSP), affect proteins that model ER shape.
The Fellow will test the model that these proteins help form axonal ER, which is disrupted when these proteins are mutated.
The time for this is opportune; the host lab has developed tools to detect impaired axon E…
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