CORDIS Project
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This project investigates the mechanisms of protein quality control in bacteria, focusing on how proteins are modified and regulated under stress. It aims to uncover the roles of specific proteins in managing misfolding and aggregation, with potential pharmaceutical implications.
Cellular proteins are prone to misfolding and aggregation, particularly under harsh environmental conditions.
To counteract this danger, all organisms from bacteria to humans evolved sophisticated protein quality control networks.
The mechanisms employed in them tend to represent some of the most exciting biochemistry occurring in living cells.In Gram-positive bacteria, the key factors combating protein damage include a specialized protein kinase phosphorylating arginine residues (McsB), the cen…
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