CORDIS Project
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This project focuses on improving immune tolerance to self-tissues and transplants by manipulating lymphocyte recovery after depletion. It aims to enhance therapeutic strategies using monoclonal antibodies to promote regulatory T-cells, potentially leading to better treatments for autoimmune diseases and organ transpla…
Unwanted immune responses to self-tissues and transplants have a major impact on human health and wealth.
Their management has required long-term immunosuppressive drugs which penalise the whole immune system.
The big challenge has been to understand how the individual is naturally tolerant to self, and to exploit this knowledge for treatments better targeted to the relevant antigens.
Since 1980 the applicant’s laboratory have, in rodent models, defined mechanisms of acquired tolerance, and use…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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