CORDIS Project
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This project investigates the role of the PAX8 transcription factor in high-grade serous carcinoma and fallopian tube secretory epithelial cells. By studying its function and genomic binding, the research aims to clarify how PAX8 influences cancer development and progression.
Epithelial ovarian cancer is a disease with grim prognosis and high-grade serous carcinoma (HGSC) is its most common subtype.
Recent literature suggests that HGSC arises in the fallopian tube (FT) epithelium, rather then in the ovary, and metastasizes to the ovary early on in the process of transformation.
This hypothesis is based, among other findings, on common morphologic and immunophenotypic traits between HGSC and the fallopian tube secretory epithelial cell (FTSEC).
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