CORDIS Project
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This project investigates the Type VI secretion system in Pseudomonas aeruginosa, a pathogen responsible for severe infections. It aims to identify novel toxins and understand their mechanisms of action, which could lead to new therapeutic strategies against infections.
Pseudomonas aeruginosa is a human pathogen that causes life-threatening nosocomial infections.
This organism has a range of virulence mechanisms, however its secretion systems play a key role in the transport of effectors, toxins and other virulence factors which are important for colonisation of niches including the human host.
One newly identified secretion system is the Type VI secretion system (T6SS) which has been identified in a number of Gram-negative bacteria.
This system is a specialise…
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