CORDIS Project
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This project focuses on developing a new process analytical technology for real-time monitoring of glycosylation in biopharmaceutical production. By utilizing a nanoplasmonic glycan-binding array, it aims to improve the quality control of therapeutic antibodies, ensuring consistent product efficacy.
Glycosylation of therapeutic antibodies is one of the most critical quality attributes (CQAs) in biopharmaceutical manufacturing because of its strong impact to the treatment efficacy.
Many parameters in the production process including upstream cell culture and downstream purification can significantly change the antibody glycosylation profiles.
Therefore, monitoring and quality controlling of glycosylation is central to ensure high quality and consistent products.
Unfortunately, this requires…
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