CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project investigates the role of the Pax5 transcription factor in the development of B lymphocytes from stem cells. By mapping Pax5 target genes across the genome, it aims to elucidate the regulatory networks involved in B cell development and immune function.
A complex network of transcription factor interactions controls the process by which B lymphocytes develop from hematopoietic stem cells (HSCs).
Pax5 has been identified as the critical transcription factor controlling B cell commitment throughout B lymphopoiesis.
These analyses revealed that Pax5 commits early hematopoietic progenitors to the B cell pathway by repressing B-lineage-inappropriate genes and by simultaneously activating B-cell-specific genes.
By comprehensive cDNA microarray analys…
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
