CORDIS Project
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This project aims to understand the role of lymphocyte-specific protein tyrosine kinases in microglia activation related to Alzheimer's disease. By developing a light-responsive system to control kinase activity, the research seeks to enhance insights into neurodegenerative disorders using zebrafish models.
Protein kinases play a critical role in a number of cellular processes, including cell proliferation, differentiation and apoptosis.
Recently, the aberrant regulation of lymphocyte-specific protein tyrosine kinases (LCK) has been associated with the over activation of microglia cells (important immune effector cells that reside in the central nervous system, CNS) and in turn, the development of Alzheimer’s disease (AD).
Unfortunately, the detail of LCK's dynamic function and the importance of qu…
UGOT - GOETEBORGS UNIVERSITET/UNIVERSITY OF GOTHENBURG
GOETEBORGS UNIVERSITET
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