CORDIS Project
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This project investigates how metabolic changes in pancreatic cancer cells influence Schwann cells to promote perineural invasion, a condition worsening patient outcomes. It employs advanced nuclear magnetic resonance techniques to enhance imaging of metabolites, aiming to identify biomarkers for early diagnosis and po…
Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with 5-year survival rate of less than 7%.
Existing treatments are limited because 90-100% of patients develop perineural invasion (PNI). PNI is associated with severe pain, poor prognosis, poor survival, and tumor recurrence, and involves nerve invasion by cancer cells, as a result of dynamic interactions between them and other cells in the tumor microenvironment (TME).
Schwann cells (SCs) are part of this TME and are activated by…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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