CORDIS Project
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This project investigates the role of gut inflammation in the onset of Parkinson's disease by exploring immune responses to intestinal pathogens. It employs advanced techniques like organoids and single-cell sequencing to uncover mechanisms linking gut health to brain function, aiming to identify potential therapeutic…
Burgeoning evidence shows that Parkinson's disease (PD) involves the gut before affecting the brain, leading to the fascinating hypothesis that the gut might be the site of disease initiation.
Remarkably, the gut origin of PD is still poorly understood.
Multiple triggers could serve as a first insult: infections, dysbiosis, and inflammatory bowel diseases (IBDs).
All these conditions ultimately converge on intestinal inflammation.
Thus, an intriguing hypothesis is that PD is a systemic illness t…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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