CORDIS Project
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This project investigates pancreatic ductal adenocarcinoma subtypes to improve therapy choices. It explores the role of transcription factors and tumor microenvironments in subtype switching, using advanced single-cell technologies to analyze tumor responses to chemotherapy, ultimately aiming to enhance patient outcome…
Recently discovered subtypes in pancreatic ductal adenocarcinoma (PDAC) have potential to better guide the choice of therapy.
However, this is challenged by the lack of robust data, patient heterogeneity, tumour cell plasticity, dynamic crosstalk with surrounding cells, and post-chemotherapy induced alterations. A few transcription factors may act as drivers of specific PDAC subtypes and changes in there expression through aberrant activation of super-enhancers may lead to ‘’subtype switching’’.…
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