CORDIS Project
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This project investigates the defense mechanisms bacteria use against viruses, focusing on the diversity of anti-phage systems and their potential connections to eukaryotic antiviral pathways. It aims to create a comprehensive map of bacterial immunity and identify new antiviral compounds for therapeutic applications.
Bacteria have evolved multiple lines of defense against their viruses, bacteriophages.
Such weapons include restriction modification and CRISPR systems that have greatly impacted biomedical research.
Studies aimed at uncovering novel defense mechanisms describe an unsuspected diversity of anti-phage systems, spanning thousands of protein families.
Several of these anti-phage systems, such as prokaryotic viperins, appear to be ancestors of major eukaryotic antiviral pathways.
This striking cons…
INSTITUT PASTEUR
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