CORDIS Project
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This project aims to elucidate the mechanisms of Cys-loop receptors in the brain, which are crucial for neurotransmission. By obtaining high-resolution structures, it seeks to advance our understanding of these receptors and their potential as drug targets.
In the brain, Cys-loop receptors mediate fast neurotransmission.
They function as allosteric signal transducers across the plasma membrane: upon binding of one or more neurotransmitter molecules to an extracellular site, the receptors undergo complex conformational transitions that result in transient opening of an intrinsic ion channel.
The Cys-loop family comprises receptors activated by serotonin, acetylcholine, glycine and GABA.
Mammalian receptors are also the targets of a legion of psycho-…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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