CORDIS Project
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This project investigates the role of amino acid shortages in cancer progression, particularly focusing on tryptophan. It aims to understand how these shortages affect protein translation in tumor cells and explore new therapeutic strategies based on these findings.
Shortages in amino acids are weapons in the warfare between tumor cells and tumor-infiltrating lymphocytes.
Tumor cells enhance or inhibit the production of key amino acid metabolites to stimulate oncogenesis and suppress anti-tumor activity. A key player in this battle is tryptophan.
Activated T cells secrete interferon-, which upregulates IDO1 enzyme to catabolize tryptophan to kynurenine in target tumor cells.
While kynurenine suppresses T-cell function, its production limits tryptophan avail…
STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
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