CORDIS Project
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This project aims to synthesize cyclic peptides with restricted mobility using the Suzuki-Miyaura reaction. The goal is to create new peptide libraries that can act as ligands for specific proteins, enhancing their potential for therapeutic applications.
The aim of this research proposal is the application of the Suzuki-Miyaura reaction to the synthesis of peptidic libraries with restricted mobility.
Specifically, we envision the synthesis of a family of cyclic peptides that will contain a biaryl bond, to further restrain their conformation.
This biaryl bond will be obtained through a Suzuki-Miyaura set of reactions between two aromatic amino acid derivatives in the sequence.
Initially, the reaction conditions will be optimized on simple models:…
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
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