CORDIS Project
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This project aims to advance synthetic biology by developing a novel method for assembling proteins using irreversible isopeptide bonds. The approach focuses on enhancing the capture of circulating tumor cells, which could improve early cancer diagnosis and understanding of cellular responses.
Our ability to tailor individual proteins is now sophisticated, but our ability to assemble such proteins into larger structures is still primitive.
Proteins are typically joined by reversible or non-specific linkages.
We have designed a unique way to connect protein building blocks irreversibly and precisely, via spontaneous isopeptide bond formation.
This involves modifying proteins with a short peptide tag (SpyTag) that is based upon remarkable chemistry used by pathogenic Gram-positive bacte…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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