CORDIS Project
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The MANGO project investigates novel antimicrobial peptides that target bacterial protein aggregation, offering a potential solution to combat antibiotic resistance. These peptides have shown effectiveness against drug-resistant bacteria without harming mammalian cells.
Antibiotic resistance is increasing globally at such a pace that many experts fear the dawn of the post-antibiotic era if we fail to meet the urgent need for novel therapeutics.
We evaluated if the working hypothesis of the MANGO ERC project that protein aggregation is driven by sequence specific interactions can be exploited to generate aggregates that are specifically toxic to bacteria without affecting mammalian cells.
In particular we examined if peptides encoding aggregation-prone sequence…
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