CORDIS Project
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This project investigates the role of peroxiredoxins in regulating reactive oxygen species and their impact on cell cycle and apoptosis in cancer cells. It aims to identify new targets for cancer therapy by manipulating these mechanisms to selectively induce cell death in tumor cells.
Peroxiredoxins (PRX) are at the heart of mechanisms gating the spatiotemporal distribution of ROS molecules within the cell and thereby deeply involved in the development or progression of disease.
With the host group’s recent discovery on the circadian nature of PRX-hyperoxidation cycles, PRXs emerge to be tested for driving the physiological 24 h periodic fluctuations of the cellular redox state and ROS-signaling, both being critical in cell cycle control.
The potential of the PRX-clock to rob…
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