CORDIS Project
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This project focuses on understanding the molecular mechanisms behind memory T cell differentiation and persistence in humans. It aims to identify factors that enhance the longevity and effectiveness of these immune cells, which are crucial for combating infections and cancers.
Defining the molecular mechanisms governing memory T cell differentiation and homeostasis is of pivotal importance to generate durable and protective T cell responses against infections and cancers.
Considerable knowledge in this regard has been acquired in mouse models but is still limited about human T cells.
In particular, some mechanisms are assumed to occur in humans but were never formally demonstrated.
We showed that memory T cells adoptively-transferred with bone marrow transplantation f…
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