CORDIS Project
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This project explores how cells regulate RNA degradation and processing, focusing on the mechanisms that determine which RNA transcripts are targeted for decay. It aims to provide insights into gene expression control and its implications for diseases.
The human genome is pervasively transcribed, producing RNA from ~ 80-90% of its DNA, yet only a small fraction of transcripts result in the generation of functional RNAs.
Instead, the majority of transcription initiation events are prematurely terminated and the resulting RNA is targeted by decay pathways.
How cells determine which RNAs to degrade vs. which to prepare for functional tasks, is a central question.
Interestingly, new data from my host laboratory, that motivates this application, su…
AARHUS UNIVERSITET
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