CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project investigates how the Plasmodium falciparum parasite regulates its virulence genes through a process called antigenic variation. By studying a novel protein family, PfAlba, the research aims to uncover mechanisms of gene expression and chromatin biology that could enhance understanding of malaria pathology.
Antigenic variation is a common strategy utilized by intracellular pathogens to evade immune detection.
Plasmodium falciparum, the causal agent of the most lethal form of malaria, modulates antigenic variation of the ~60 member 'var' virulence gene family by exhibiting mutually exclusive, monoallelic expression.
This is achieved by spatially and epigenetically regulating var transcription such that silent var loci cluster at the nuclear periphery and are associated with nucleosomes modified by s…
INSTITUT PASTEUR
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
