CORDIS Project
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This project investigates the side effects of thiazolidinediones, a class of drugs used to treat type 2 diabetes, particularly focusing on their impact on the cardiovascular system. By exploring the role of specific genetic factors, the research aims to better understand the mechanisms behind these adverse effects.
Thiazolidinediones (TZDs) are clinically proven insulin sensitizers with anti-inflammatory benefits used in the therapy of type 2 diabetes mellitus (T2DM) and atherosclerosis. TZDs can activate a transcription factor, the peroxisome proliferator-activated receptor gamma (PPARg). PPARg regulates expression of several genes involved in inflammatory pathways, lipid transport and carbohydrate metabolism.
Antidiabetic effects of TZDs have been coupled to macrophages, since tissue macrophages can prod…
CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.)
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