CORDIS Project
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This project investigates how the immune system recognizes bacterial components, specifically peptidoglycan, using pattern recognition receptors. By employing various experimental techniques, it aims to enhance our understanding of immune responses, potentially leading to improved treatments for inflammatory diseases a…
The immune system of higher organisms is using pattern recognition receptors (PPR) of the host cell to fight pathogenic bacteria by recognizing molecular signatures called Pathogen Associated Molecular Patterns (PAMP) unique to the bacteria but absent from the host.
Bacterial cell wall peptidoglycan (PGN), a polymer of disaccharide-pentapeptide repeating units is one of the most important PAMPs.
Fragments of PGN and related small molecules can also elicit immune response i.e., act as PAMPs.
Alth…
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