CORDIS Project
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The PHAGO project focuses on understanding and modifying the immune response in Alzheimer's disease by targeting specific receptors involved in inflammation and neurodegeneration. It aims to develop tools and strategies to manipulate immune cell activity to reduce disease risk and advance treatment options.
Alzheimer’s disease (AD) is an age-related chronic neurodegenerative disease with four main pathological changes in the brain: amyloid plaques, fibrillary tau tangles, inflammation and neuronal loss.
Phagocytes around amyloid plaques in late onset AD (LOAD) may be neurotoxic but have limited motility and phagocytic activity, suggesting a dysfunctional activation.
These phagocytes express the innate immune receptor TREM2 and CD33.
Variants of both genes have been linked to LOAD.
The main objectiv…
UNIVERSITATSKLINIKUM BONN
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Belgium, Beerse
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: No
United Kingdom, London
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany, Berlin
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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