CORDIS Project
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This project investigates the roles of protein-S and Gas6, two vitamin K-dependent proteins, in regulating the phagocytosis of apoptotic cells during cell differentiation. Using genetically modified mice and rats, the research aims to establish new assays for phagocytosis and explore connections between blood coagulati…
The anti-coagulant factor protein-S and its structural homologue Gas6, two vitamin K-dependent proteins, are ligands for the Tyro3/Axl/Mer family of related tyrosine kinase receptors.
Protein-S is the major factor responsible for serum-stimulated phagocytosis of apoptotic cells.
The phenotypes associated with the invalidation of genes encoding Tyro3/Axl/Mer, further revealed the implication of protein-S and Gas6, in regulating apoptotic cell phagocytosis.
We hypothesise that protein-S and Gas6…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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