CORDIS Project
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This project investigates how dendritic cells process and present antigens after phagocytosing pathogens. It aims to understand the molecular mechanisms regulating phagosomal functions during dendritic cell maturation, which is crucial for initiating adaptive immune responses.
Integrative phagosomal biology: antigen presentation and developmental programs in dendritic cells Dendritic cells phagocytose incoming pathogens and dead cells in peripheral tissues, and then migrate to the draining lymph nodes where they deliver to lymphocytes all the information required for the initiation of adaptive immune responses.
This information relates to the nature of the pathogen, which is sensed, both directly through pattern recognition receptors (including Toll-like receptors…
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