CORDIS Project
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This research focuses on understanding how the immune system combats pathogens that invade host cells. Specifically, it examines the role of Guanylate-Binding Proteins in disrupting phagosomes to eliminate these pathogens, using advanced imaging techniques to explore the structural dynamics of these proteins during imm…
Our immune system provides a formidable barrier to the many microbial pathogens that we encounter every day.
Yet, many pathogens have the ability to avert this barrier by invading the host cell and seeking shelter inside a phagosome whose membrane physically prevents the pathogen from being recognized and eliminated.
Cell-autonomous immunity is a part of the innate immune system that fights off such pathogens.
Among the antimicrobial effectors mobilized by this immune response are the Guanylate-…
TECHNISCHE UNIVERSITEIT DELFT
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