CORDIS Project
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This project explores the formation and dysfunction of ribonucleoprotein granules, which are linked to neurodegenerative diseases like amyotrophic lateral sclerosis. It aims to identify the molecular mechanisms that lead to these defects and their role in disease progression.
Recent studies suggest that defective ribonucleoprotein (RNP) granules and altered RNA processing cause neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
However, defective RNP granules only develop late in life, suggesting that young cells have mechanisms in place to prevent their formation.
We recently demonstrated that physiological RNP granules form through phase separation in the cytoplasm and adopt a liquid-like state, but with tim…
TECHNISCHE UNIVERSITAET DRESDEN
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