CORDIS Project
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This project investigates how phosphate levels are regulated in cells, focusing on the role of inositol pyrophosphates in energy metabolism using the amoeba Dictyostelium discoideum. It aims to understand the relationship between phosphate homeostasis and energy production, particularly during the organism's developmen…
Adenosine triphosphate (ATP) is the universal biological energy currency.
Its cellular concentration is tightly regulated and depends on rates of glycolysis, oxidative phosphorylation, and obviously on phosphate availability.
How is phosphate concentration regulated as a function of the cell’s demands?
Inositol pyrophosphates, described as metabolic messengers, are excellent candidates to orchestrate phosphate homeostasis and energy metabolism.
The research programme proposed here aims to elucid…
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