CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project investigates a treatment for Autosomal Dominant Optic Atrophy (ADOA), a hereditary condition causing vision loss due to mitochondrial dysfunction in retinal ganglion cells. By using autophagy inhibitors delivered via nanocarriers, the aim is to restore mitochondrial function and prevent visual decline in a…
Autosomal dominant optic atrophy (ADOA) is the most common hereditary neuropathy that affects 1:35.000 people worldwide. A progressive visual loss is a characteristic of ADOA, and a treatment is not available.
Mutations in the nuclear gene Optic Atrophy 1 (OPA1) in ADOA patients promote low levels of OPA1 protein, causing Retinal Ganglion Cells (RGCs) degeneration leading to blindness. OPA1 is the key component for mitochondrial inner membrane fusion mechanism and controls cristae biogenesis and…
UNIVERSITA DEGLI STUDI DI PADOVA
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
Guests see up to 5 keywords.
