CORDIS Project
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PHERON aims to improve treatment for colorectal cancer by developing a new drug delivery system that targets tumor sites. The project focuses on using a specific inhibitor to disrupt the immunosuppressive environment of tumors, enhancing the effectiveness of immunotherapy.
Colorectal cancer (CRC) was estimated to be the second most commonly diagnosed cancer in Europe. CRC can be classified into subtypes based on distinct molecular and clinical features, termed consensus molecular subtypes (CMS 1-4).
The proportion of CMS4 was 38.5% in CRC stage IV patients, only 6% of whom had a 5-year survival rate. CMS4 CRC is highly malignant and characterized by a richness of stromal fibroblasts and, consequently, an increased expression of mesenchymal genes.
The sialylation o…
UNIVERSIDADE NOVA DE LISBOA
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