CORDIS Project
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This project explores the role of the long pentraxin PTX3 in the innate immune system, focusing on its functions in tissue repair and cancer-related inflammation. It aims to uncover how PTX3 interacts with the immune response and its potential role as an oncosuppressor.
The innate immune system includes a cellular and a humoral arm.
Structural diversity is a characteristic of humoral fluid phase pattern recognition molecules.
These include complement components, collectins, ficolins, and pentraxins.
We have used the long pentraxin PTX3, identified by the applicant (cDNA and genomic, mouse and human), as a prototypic fluid phase pattern recognition molecule to dissect its function, as well as to define general properties of humoral innate immunity and its in…
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