CORDIS Project
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The project aims to understand the role of protein phosphorylation in yeast by developing genetic methods to study its functional relevance. It will analyze phosphoproteomic data to identify critical phosphorylation sites and their evolutionary significance.
Cells have evolved intricate systems to sense environmental changes and an initial response to such cues is often driven by post-translational modifications (PTMs) of proteins.
Protein phosphorylation is an abundant PTM that modulates protein function via diverse mechanisms.
Improvements in mass-spectrometry are unveiling a complex world of PTM regulation with thousands of phosphosites routinely identified per study.
We and others have recently shown that phosphosites can diverge quickly during…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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