CORDIS Project
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This project explores the mechanisms of phosphate ester hydrolysis, crucial for biological processes, by studying specific enzymes involved in nucleic acid processing and HIV reverse transcriptase. It aims to inform drug design against HIV resistance.
Phosphate ester hydrolysis is one of the most important classes of chemical reactions in biology, playing a central role in nucleic acid processing, energy transduction, and signalling.
Despite the importance of this ubiquitous reaction, the mechanistic details of phosphate ester cleavage remain obscure due to the complex nature of the reaction.
In addition, there is an active debate concerning possible reaction intermediates.
Here we aim to clarify the molecular basis of this enzymatic mechanis…
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