CORDIS Project
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This project investigates multisite phosphorylation in protein regulation, particularly its role in cell cycle control. It aims to understand how phosphorylation patterns affect cellular processes and explore applications in synthetic biology.
Multisite phosphorylation of proteins is a powerful signal processing mechanism playing crucial roles in cell division and differentiation as well as in disease.
Our goal in this application is to elucidate the molecular basis of this important mechanism.
We recently demonstrated a novel phenomenon of multisite phosphorylation in cell cycle regulation.
We showed that cyclin-dependent kinase (CDK)-dependent multisite phosphorylation of a crucial substrate is performed semiprocessively in the N-to…
TARTU ULIKOOL
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