CORDIS Project
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This project investigates the potential of novel ruthenium-based compounds as anticancer drugs and photosensitizers for photodynamic therapy. By employing a prodrug approach and targeting cancer cells, the research aims to enhance treatment efficacy while minimizing side effects.
In this grant application, I propose to investigate in-depth the potential of novel inert Ru(II) polypyridyl complexes as novel anticancer drug candidates.
Such compounds were investigated by Dwyer and Shulman in 1950s and 1960s both in vitro and in vivo with relatively promising results.
This impressive seminal work was unfortunately not followed-up.
This lack of additional studies was recently attributed, at least in part, to the observed neurotoxicity of the complexes.
Nonetheless, over the l…
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