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The PhotonSignaling project investigates how non-visual opsins in mammals can be activated by internal sources, specifically through redox-induced reactions. This research aims to uncover the mechanisms and physiological effects of this novel signaling pathway in mouse neurons, potentially reshaping our understanding o…
Vision is enabled by photoreceptor proteins in the eye called opsins.
In addition to visual opsins, mammals also possess three non-visual opsins, which are highly conserved and also expressed in extra-ocular tissues such as the brain.
Recent studies in live mice have shown that these non-canonical opsins are both light-responsive and physiologically active.
However, the poor penetration of visible light through hair, skin, bone, and tissue, raises intriguing questions about whether environmental…
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
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