CORDIS Project
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This project aims to enhance heart regeneration after myocardial infarction by creating localized hypoxia in damaged heart tissue using 3D bioprinted fibrin scaffolds. These scaffolds will deliver a hypoxia-mimicking agent and cardiomyocytes derived from induced pluripotent stem cells to promote heart cell proliferatio…
Ischemic heart disease is the main cause of death in Europe and the world, and its main manifestation is myocardial infarction (MI).
The MI leads to loss of heart tissue, tissue scarring associated with fibrosis, dysfunction and heart failure.
The pathophysiological basis of heart failure in humans lies in the heart's inability to regenerate.
Adult cardiomyocytes (CMs) perform mitosis after MI, but their proliferation rate is extremely low for restoring normal cardiac function.
During developmen…
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
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