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PHYRIST investigates the ribotoxic stress response, which is triggered by ribotoxins and UV radiation, affecting ribosome integrity. The project aims to understand its role in inflammation and cancer development, potentially identifying new therapeutic targets for skin cancer and other conditions.
The ribotoxic stress response (RSR) surveys the structural and functional integrity of ribosomes and is triggered by diverse groups of ribotoxins (e.g. ricin), UV irradiation and some chemotherapeutics.
When presented with impaired ribosomes, the proximal MAPKKK ZAK activates MAP kinases p38 and JNK to initiate a powerful inflammatory response.
This signalling contributes to the detrimental reactions to ribotoxins and fatal side effects of cancer therapy.
However, despite decades of research int…
KOBENHAVNS UNIVERSITET
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