CORDIS Project
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This research project investigates the roles of class II phosphoinositide 3-kinases, specifically PI3K-C2alpha and PI3K-C2beta, in metabolic signaling and cancer. Using innovative mouse models, the study aims to understand their physiological functions and interactions with other signaling pathways, contributing to pot…
Phosphoinositide 3-kinases (PI3Ks) are a conserved family of lipid kinases that generate lipid second messengers inside cells.
Mammals have 8 isoforms of PI3K, divided in three classes (I, II and III).
The focus of research has thus far almost exclusively been on class I PI3Ks, which have been implicated in cancer, inflammation and diabetes and which are the target of ongoing drug development efforts in Pharma.
Very little is known about the other PI3Ks, in particular the class II PI3Ks, which c…
QUEEN MARY UNIVERSITY OF LONDON
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