CORDIS Project
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This project investigates the role of serotonin in working memory by studying neuronal mechanisms in the prefrontal cortex. It aims to understand how serotonin affects neuronal activity and contributes to cognitive functions, particularly in conditions like schizophrenia.
The prefrontal cortex (PFC) is essential for higher cognitive tasks such as learning, decision making and, in particular, working memory (WM).
To fulfill these tasks, PFC neurons express several serotonin (5HT) receptor subtypes that are modulated by a high density of serotonergic axons projected from the raphe nuclei.
Alterations of the neuronal mechanisms within PFC lead to an impaired top-down regulation, causing cognitive dysfunctions in mental disorders such as schizophrenia. A key cellular…
THE FRANCIS CRICK INSTITUTE LIMITED
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IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom, LONDON
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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