CORDIS Project
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This project investigates pioneer transcription factors (pTFs) to understand their unique ability to alter chromatin structure and influence cell fate. By employing single-molecule spectroscopy, the research aims to map the conformational states and kinetic mechanisms of pTFs, ultimately enhancing cell reprogramming te…
Pioneer transcription factors (pTFs) have unique capabilities beyond classical TFs:
They can invade and open closed chromatin, initiating cell-fate changes.
Their remarkable abilities have been used to steer cell-fate decisions and to induce a pluripotent stem cell state through poorly understood pathways.
Like most TFs, pTFs consist of structured DNA-binding domains (DBDs) flanked by long intrinsically disordered regions (IDRs).
In attempts to explain their pioneering functions, intense focus h…
KOBENHAVNS UNIVERSITET
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Iceland, Reykjavik
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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