CORDIS Project
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This project investigates the regulation of RNA transcription during the elongation phase, focusing on how transcription cofactors influence the kinetic competition between termination and pausing in bacteria. Using advanced biophysical techniques, it aims to develop agents that can modify this regulation to treat infe…
Since RNA transcription is an important early step in the process of gene expression, it is tightly regulated at all its constituent phases.
These include initiation of transcription, elongation and termination of the process at the end of the gene or operon.
Post-initiation regulation of RNA transcription during the elongation phase by the alternative pathways of termination, pausing or elongation allows the cell or organism subtle control over the expression of genes that are constitutively…
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