CORDIS Project
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This project investigates how the PIWI interacting RNA pathway in fruit flies protects the genome from transposable elements. It aims to understand the mechanisms of RNA silencing and chromatin biology, focusing on how these processes influence gene expression and transposon management.
Transposable elements—universal components of genomes—pose a major threat to genome integrity due to their mutagenic character.
In all eukaryotic lineages small RNA pathways act as defense systems to protect the host genome against the activity of transposons.
The central pathway in animals is the gonad-specific PIWI interacting RNA (piRNA) pathway, one of the most elaborate but also least understood small RNA silencing systems.Here I propose to study the interplay between the piRNA pathway and…
INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH
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