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PLAS-FIGHTER aims to combat antibiotic resistance by investigating how plasmids in bacteria affect their physiology and susceptibility to antibiotics. The project will utilize advanced screening techniques to identify new treatment targets and develop strategies informed by ecological and evolutionary principles.
The discovery of antibiotics revolutionised the fight against infectious diseases and paved the way for modern medicine.
However, widespread use of antibiotics has driven rampant evolution of antimicrobial resistance (AMR) in bacteria.
The main route for AMR acquisition in clinically important bacteria is the horizontal transfer of plasmids (conjugation-competent mobile genetic elements) carrying resistance genes. AMR plasmids allow bacteria to survive antibiotics, but they also entail physiolog…
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